The 26-year-old Jackson had started the first 27 games of the season in center field and had batted leadoff every game until Friday.
"He did not ask for a day off," said Tigers manager Jim Leyland. "He could play. He's played in all of them. It's not that easy."
Jackson, who had three hits on Thursday and entered Friday's action with an American League-leading 28 runs, is dealing with a sore hamstring.
"It doesn't matter how old you are, sometimes you get tired," said Leyland.
Richard Dean is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.