Tigers manager Jim Leyland doesn't know when to anticipate Guillen's return.
"No idea," Leyland said in a swift pregame press session.
Guillen, who has experienced back trouble twice in the last six days, reported numbing pain in his right lower back, right leg and right foot. He said he has trouble lifting his right leg, which hinders his ability to run and hit.
A three-time All-Star, Guillen said he has felt the pain for about one week, but the pain just recently became unbearable.
Ramon Santiago started at third in place of Guillen in Wednesday's game against the Blue Jays. Brandon Inge and Ryan Raburn represent other options Leyland could use while one of his team leaders recovers.
Scott McNeish is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.